ABSTRACT
Background: Siddha medicine is one of the oldest herbal medication after Ayurveda. For many centuries, siddha medicine is being used to cure or prevent many diseases including cancer. MahaVellathyLehyam is one such Siddha medicine possessing characteristic nature against cancer. The main objective of this study is to explicate the potential of MVL as a chemopreventive agent by analysing the alterations in lipidperoxidation, membrane bound enzymes and glycoconjugates against 4-Nitroquinoline-1-oxide (4NQO) induced rat oral carcinogenesis. Materials and methods: The male wistar rats were subjected to the carcinogen 4NQO and the activity of MVL against the carcinogenic cells was studied through lipid peroxidation, membrane bound ATPases (Na+ /K+ ATPase, Ca2+ ATPase and Mg2+ ATPase) and protein bound carbohydrate components (protein bound hexose, hexosamine, sialic acid and fucose). Results: The obtained result was visualized as an increase in the expression of the lipid peroxidation of the tongue tissue, membrane bound ATPases and glycoconjucates indicating oxidative stress induced by the carcinogen 4QNO. Priyanka G, Kayalvizhi E, Madan Kumar A, Chinmayi Sri Amulya Y, Rajajeyakumar Manivel. Chemopreventive effect of Maha Vallathy leghiyam on 4-Nitroquinoline-1-oxide induced oral carcinogenesis in wistar rats. IAIM, 2019; 6(7): 28-36. Page 29 Conclusions: The administration of MVL has caused a significant decrease in these aspects suggesting the nature of MVL against the carcinogenic nature of 4NQO by efficiently decreasing the oxidative damage.